¿µ½¡ÖйúÊÜÊÔÕßµ¥´ÎºÍ¶à´Î¾²Âö×¢ÉäÁòËáð¤¾úËØµÄÒ©´ú¶¯Á¦Ñ§ºÍÇå¾²ÐÔ
Ðû²¼Ê±¼ä£º2024-09-26
ÓижøÈ¾ 2024Äê09ÔÂ23ÈÕ 01:58
2024Äê9Ô£¬£¬£¬£¬£¬£¬¸´µ©´óѧÁ¥ÊôÉϺ£»£»£»£»£»£Î÷ÔÀÒ½Ôº¿¹ÉúËØÑо¿ËùÕÅݼ½ÌÊÚÍŶÓÔÚInternational Journal of Antimicrobial Agents½ÒÏþÁË¡°¿µ½¡ÖйúÊÜÊÔÕßµ¥´ÎºÍ¶à´Î¾²Âö×¢ÉäÁòËáð¤¾úËØµÄÒ©´ú¶¯Á¦Ñ§ºÍÇå¾²ÐÔ¡±£¬£¬£¬£¬£¬£¬ÌâΪPharmacokinetics and safety of colistin sulfate after single and multiple intravenous doses in healthy Chinese subjects¡£¡£
Åä¾°£º¿¹¾úËØÄÍÒ©ÐÔµÄÔöÌíµ¼Ö¶àð¤¾úËØ×÷Ϊ¶àÖØÄÍÒ©¸ïÀ¼ÊÏÒõÐÔ¾úѬȾµÄ×îÓÐÓÃÖÎÁÆÑ¡Ôñ¡£¡£ÁòËáð¤¾úËØµÄ³¦ÍâÖÆ¼Á½öÔÚÖйúÓÐÊÛ¡£¡£ËäÈ»¾²ÂöµÎ×¢ÁòËáð¤¾úËØµÄ×÷ÓÃÆðЧ¿ÉÄÜ±ÈÆäǰҩ CMS ¸ü¿ì£¬£¬£¬£¬£¬£¬µ«ÆäÒ©´ú¶¯Á¦Ñ§ £¨PK£© ÌØÕ÷ÈÔ²»ÇåÎú¡£¡£
ÒªÁ죺ÕâÏîµ¥ÖÐÐÄ¡¢¿ª·Å±êÇ©¡¢µ¥¼ÁÁ¿ºÍ¶à¼ÁÁ¿¡¢1 ÆÚÊÔÑé¼ì²éÁËÁòËáð¤¾úËØÔÚ¿µ½¡Öйú³ÉÈËÖÐµÄ PKs ºÍÇå¾²ÐÔ¡£¡£¼ÓÈëÕßͨ¹ý 2 Сʱ¾²ÂöÊä×¢½ÓÊܵ¥´Î 10000 µ¥Î»/kg£¨Ï൱ÓÚ 0.452 mg/kg£©¼ÁÁ¿µÄÁòËáð¤¾úËØ£¨µ¥¼ÁÁ¿×é;n=12£©»òÏàͬ¼ÁÁ¿Ã¿ 12 Сʱһ´Î£¬£¬£¬£¬£¬£¬Ò»Á¬ 7 Ì죨¶à¼ÁÁ¿×飬£¬£¬£¬£¬£¬n=12£©¡£¡£Ê¹Óà LC-MS/MS ²â¶¨Ñª½¬ºÍÄòÒºÖеÄð¤¾úËØÅ¨¶È£¬£¬£¬£¬£¬£¬²¢Ê¹Ó÷Ƿ¿ÊÒÆÊÎöÅÌËã PK ²ÎÊý¡£¡£
Ч¹û£ºµ¥´Î¸øÒ©ºó£¬£¬£¬£¬£¬£¬·åŨ¶È £¨Cmax£©¡¢0 ÖÁ 12 СʱµÄÇúÏßÏÂÃæ»ý £¨AUC0-12h£©¡¢ÖÕÄ©°ëË¥ÆÚ £¨T1/2£©¡¢ÂþÑÜÈÝ»ý £¨Vd£©ºÍð¤¾úËØµÄÌå×Üɨ³ýÂÊ £¨CL£© »®·ÖΪ 1.08 ¡À 0.18 mg/L ¡¢ 4.73 ¡À 0.89 h¡¤mg/L¡¢ 3.65 ¡À 0.55 h¡¢ 16.82 ¡À 2.70 L ºÍ 3.24 ¡À 0.51 L/h¡£¡£¶à´Î¸øÒ©ºóδÊӲ쵽ÁòËáð¤¾úËØÐî»ý¡£¡£¶à¼ÁÁ¿¸øÒ©ºó 24 СʱÄÚÁòËáð¤¾úËØµÄÀÛ»ýÄò½ÓÄÉÂÊΪ 0.9 ¡À 0.7%¡£¡£Î´¼ûÉö¶¾ÐÔ±¨¸æ¡£¡£
½áÂÛ£º±¾Ñо¿Ê״ᨵÀÁ˵¥¼ÁÁ¿ºÍ¶à¼ÁÁ¿ÁòËáð¤¾úËØ¸øÒ©ºóÖйú¿µ½¡ÊÜÊÔÕßµÄ PKs¡£¡£PK ºÍÇå¾²ÐÔÊý¾ÝÊÇÁÙ´²Êµ¼ùÖÐ×î¼Ñ¼ÁÁ¿Ñ¡ÔñËù±ØÐèµÄ¡£¡£
Ê×´ÎÔÚ¿µ½¡ÖйúÊÜÊÔÕßÖÐÑо¿ÁË0.452 mg/kg ÁòËáð¤¾úËØµ¥´ÎºÍ¶à´Î¾²Âö¸øÒ©ºóµÄPKÌØÕ÷¡£¡£ÁòËáð¤¾úËØµÄCmaxÔÚÊäÒº¿¢ÊÂʱ¼´µÖ´ï£¬£¬£¬£¬£¬£¬Ò»Á¬7ÌìÖØ¸´¸øÒ©ºóδÊӲ쵽ð¤¾úËØµÄÐî»ý¡£¡£¶à¼ÁÁ¿Ñо¿Åú×¢£¬£¬£¬£¬£¬£¬ÁòËáð¤¾úËØÍ¨¹ý·ÇÉö;¾¶ÉøÍ¸¡£¡£¸ÃÑо¿Îª¿µ½¡ÊÜÊÔÕßÖÐð¤¾úËØµÄPKÌØÕ÷ÌṩÁË»ù´¡ÖªÊ¶¡£¡£ÓÐÐëÒª½øÒ»²½Ñо¿ÁòËáð¤¾úËØµÄPK/PDÌØÕ÷¼°ÆäÓëÁÙ´²ÁÆÐ§µÄÏà¹ØÐÔ¡£¡£
ÔÎÄÏÂÔØÍøÖ·£º
https://doi.org/10.1016/j.ijantimicag.2024.107326
ÉÏһƪ£ºÎÒ¹úÄâ¶ÔÒßÃçÖÎÀíµ¥×ÔÁ¦·¨
¹ØÓÚ¼ÎÓÓ
¹«Ë¾¸Å¿ö×éÖ¯¼Ü¹¹ÉùÓþ×ÊÖÊÎÄ»¯ÀíÄî²úƷЧÀÍ
Ò½Ò©ÊÖÒÕ¿ª·¢Ò½Ò©ÊÖÒÕÍÆ¹ãÒ©ÆóÖÎÀí×Éѯ¿µ½¡ÖÎÀíЧÀÍÐÂÎÅ×ÊѶ
¹«Ë¾ÐÂÎÅÐÐÒµ×ÊѶÁªÏµng28ÄϹ¬ÓéÀÖ¹ÙÍø
ÁªÏµ·½·¨ÔÚÏß×Éѯɨһɨ
ÓÑÇéÁ´½Ó