ÓижøÈ¾ 2024Äê09ÔÂ17ÈÕ 23:58 ºÓ±±
2024Äê8Ô£¬£¬£¬£¬£¬£¬ÖÐÄÏ´óÑ§ÏæÑÅÈýҽԺлÔÃÁ¼½ÌÊÚÔÚJournal of Antimicrobial Chemotherapy£¨2024ÄêIF3.9£©½ÒÏþÁË¡°Õ¹Íû¶àð¤¾úËØÓÕµ¼Éö¶¾ÐÔµÄÊÔµãÁÙ´²Î£º¦Ä£×Ó£ºÒ»ÏîÕæÊµÌìÏ»ØÊ×ÐÔÐÐÁÐÑо¿¡±£¬£¬£¬£¬£¬£¬ÌâΪA pilot clinical risk model to predict polymyxin-induced nephrotoxicity: a real-world, retrospective cohort study¡£¡£¡£¡£
Ä¿µÄ£º¶àð¤¾úËØÓÕµ¼µÄÉö¶¾ÐÔ £¨PIN£© ÊÇÁÙ´²Êµ¼ùÖеÄÖ÷ÒªÇå¾²ÎÊÌâºÍÌôÕ½£¬£¬£¬£¬£¬£¬ÏÞÖÆÁ˶àð¤¾úËØµÄÁÙ´²Ó¦Óᣡ£¡£¡£±¾Ñо¿Ö¼ÔÚÊÓ²ìΣº¦ÒòËØ²¢¿ª·¢Ò»ÖÖÓÃÓÚ PIN ÔçÆÚÕ¹ÍûµÄÆÀ·Ö¹¤¾ß¡£¡£¡£¡£ÒªÁì:ÍøÂç¾²Âö×¢Éä¶àð¤¾úËØB»òÁòËáð¤¾úËØÁè¼Ý24 hµÄÎ£ÖØ»¼Õß×ÊÁÏ¡£¡£¡£¡£Ê¹ÓÃ×îС¾ø¶ÔËõ¶ÌºÍÑ¡ÔñËã×Ó(LASSO)µÄÂß¼»Ø¹éÀ´Ê¶±ðÓëЧ¹ûÏà¹ØµÄ±äÁ¿¡£¡£¡£¡£½ÓÄɼ«ÏÞÌݶÈÔöÇ¿(eXtreme Gradient Boosting, XGB)·ÖÀàÆ÷Ëã·¨¶Ô²î±ðÏÔÖøµÄÒò×Ó¾ÙÐнøÒ»²½¿ÉÊÓ»¯¡£¡£¡£¡£Í¨¹ý¶þÔªlogistic»Ø¹éÆÊÎö½¨ÉèPINÕ¹ÍûÄ£×Ó£¬£¬£¬£¬£¬£¬²¢¶ÔÄ£×Ó¾ÙÐÐʱ¼äÑéÖ¤ºÍÍⲿÑéÖ¤¡£¡£¡£¡£×îºó£¬£¬£¬£¬£¬£¬½¨ÉèÁË»ùÓÚÕ¹ÍûÄ£×ÓµÄΣº¦ÆÀ·Öϵͳ¡£¡£¡£¡£Ð§¹û:508Àý»¼ÕßÖУ¬£¬£¬£¬£¬£¬161Àý(31.6%)±¬·¢PIN¡£¡£¡£¡£¶àð¤¾úËØÀàÐÍ¡¢¸ººÉ¼ÁÁ¿¡¢Ñ¬È¾ÐÔÐݿˡ¢ºÏ²¢Ñª¹Ü¼ÓѹҩÎïºÍ»ùÏßѪÄòËØµª(BUN)ˮƽ±»ÒÔΪÊÇPINµÄÏÔÖøÕ¹ÍûÒòËØ¡£¡£¡£¡£ËùÓÐÑéÖ¤¶¼ÌåÏÖ³öºÜ´óµÄÅбðÐÔ£¬£¬£¬£¬£¬£¬ÄÚ²¿ÑéÖ¤µÄAUCΪ0.742 (95% CI: 0.696-0.787)£¬£¬£¬£¬£¬£¬Ê±¼äÑéÖ¤µÄAUCΪ0.708 (95% CI: 0.605-0.810)£¬£¬£¬£¬£¬£¬ÍⲿÑéÖ¤µÄAUCΪ0.874 (95% CI: 0.759-0.989)¡£¡£¡£¡£¿£¿ª·¢ÁËÒ»ÖÖ¼òÆÓµÄΣº¦ÆÀ·Ö¹¤¾ß£¬£¬£¬£¬£¬£¬×ÜΣº¦ÆÀ·Ö¹æÄ£Îª-3 ~ 4£¬£¬£¬£¬£¬£¬¶ÔÓ¦PINµÄΣº¦¹æÄ£Îª0.79% ~ 81.24%¡£¡£¡£¡£ÔÚ¸ÃÑо¿ÖУ¬£¬£¬£¬£¬£¬ÁòËáð¤¾úËØ×é143Àý£¬£¬£¬£¬£¬£¬ÆäÖÐ31Àý±¬·¢AKI£¬£¬£¬£¬£¬£¬ÁòËá¶àð¤¾úËØB×é334Àý£¬£¬£¬£¬£¬£¬ÆäÖÐ130Àý±¬·¢AKI¡£¡£¡£¡£ÁòËáð¤¾úËØ VS ÁòËá¶àð¤¾úËØBÓÕµ¼AKIµÄ±ÈÀýΪ17.8% vs 38.9%£¬£¬£¬£¬£¬£¬P£¼0.001¡£¡£¡£¡£ÇãÏòÆ¥Åä¶ÓÁк󣬣¬£¬£¬£¬£¬ÁòËáð¤¾úËØ VS ÁòËá¶àð¤¾úËØBÓÕµ¼AKIµÄ±ÈÀýΪ17.8% vs 40.8%£¬£¬£¬£¬£¬£¬P£¼0.001¡£¡£¡£¡£





